Gamma-aminobutyric Acid (GABA) Producing Probiotic Lactiplantibacillus Pentosus Isolated from Fermented Spider Plant (Pak Sian Dong) in Thailand

Psychobiotics are defined as the organisms that can provide mental health benefit. The possible mechanism of psychobiotics is manipulation neurotransmitter production and by microbes. lactobacillus group has been reported for potential production, especially g-aminobutyric acid (GABA) which an important inhibitory neurotransmitter. Therefore, GABA be used relaxation applied in various psychiatric disorders. aim this study was determination lactic bacterial isolates from Pak Sian Dong Thailand producing ability. results found there were 3 isolates, SF66, SF80 SF82, revealed ability to produce glutamic decarboxylase (GAD) enzyme. detected thin layer chromatography (TLC) high-performance liquid (HPLC) culture containing 3% monosodium glutamate. survival gastrointestinal synthetic condition only SF66 isolate showed authentic percentage then selected. From identification, identified Lactiplantibacillus pentosus designated L. exhibited with further investigation development psychobiotics.